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The concentration of GHK-Cu declines with age

Metabolic perturbations in the adipose tissue of individuals with obesity arise as a consequence of mitochondrial dysfunction and endoplasmic reticulum stress within the cellular milieu (44)

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The open-label study design used in the remaining three intervention studies left them at high risk of selection, performance and detection bias [46, 49, 65], however, all studies provided complete outcome data and full reporting of results